Miltiadis Varvitsiotis was born in Athens in 1969. He is a Supreme Court lawyer. He is a graduate of Athens College and the University of Athens School of Law. He also holds a postgraduate degree in international relations from Harvard University. He speaks English, French and Italian.

His political activity began in O.N.NE.D., the Youth Organization of the New Democracy Party. He was elected a member of Parliament on the New Democracy ticket in the Athens B constituency in the elections of 2000, 2004, 2007, 2009, May and June 2012, and January and September 2015. In the July 2019 election, he was elected M.P. for the Athens B2 (West) constituency.

Mr. Varvitsiotis served as deputy minister of foreign affairs for economic diplomacy and development assistance from January 2009 to October of that year, when the government changed. He also served as minister for shipping, maritime affairs and the Aegean from June 2013 to January 2015. From September 2007 to January 2009 and from July 2012 to June 2013, he served as chairman of the Parliamentary Standing Committee on Defense and Foreign Affairs, and he has sat on many other parliamentary committees.